Rashami Desai born in Nagaon to a Gujarati family in India. She did school life from Ulubari High School. Rashami is also a know Kathak and Bharatnatyam dance. She started her career with Ravan serial on Zee TV by Meet Mila De Rabba on Sony TV and started acting in the show Uttaran on Colors on 20 June 2009. Later, in March 2012 she opted out of the show Uttaran as she didn't believe she could portray an older role after the leap.
Rashmi also worked in various serials including Pari Hoon Main. She has also done episodes for Ssshhhh...Phir Koi Hai. She has featured in reality shows such as Comedy Circus, Maha Sangram, Zara Nachke Dikha, Crime Patrol, Big Money, Rashami married to Nandish Sandhu Desai who was her co-star, Nandish Sandhu, since 12 February 2012.